Rapid Review Notes About Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus (SLE)

• Commonest cutaneous eruption in Systemic Lupus Erythmatosus is Erythema of light exposed
area
• Criteria for diagnosis of systemic lupus erythematosus includes Photosensitivity, Malar rash
,Discoid rash
• 22% of patients with disseminated discoid lupus erythematosus develops SLE
• Anti Ro autoantibodies is most suggestive of subacute cutaneous lupus erythematosus
• High titers of Anti dsDNA are considered to be highly specific for Systemic lupus erythematosus
• Neonatal lupus erythematosus (NLE) is characterized by Cutaneous lesions, Heart block
& Thrombocytopenia
• Libman-Sacks endocarditis may develop with systemic lupus erythematosus
• Woman with systemic lupus erythematosus (SLE) and chronic renal failure develops anemia
because of IgG directed against red blood cells


• There may be an increase in spontaneous abortions and prematurity in patient with SLE planning
for pregnancy
• Diffuse proliferative is the most common histological type of nephritis seen in systemic lupus
erythematosus (SLE)
• Children born to mothers with systemic lupus erythematosis are likely to have Complete heart
block
• Characteristic feature of SLE is Polyserositis
• Autoimmune Hematolytic Anemia & Anti-ds DNA are seen in SLE
• In SLE, characteristic kidney lesion is Wire loop lesions
• Indications of steroids in SLE are Endocarditis
• SLE is Type III hypersensitivity reaction
• Onion skin spleen is seen in SLE
• Normal CRP with elevated ESR seen in SLE
• Skin biopsy of SLE patient using RTC labeled human IgG antiserum shows deposition of irregular
particles at dermoepidermal junction. This means there is presence of Immune complex deposits
• SLE is can cause both cicatricial as well as noncicatrical alopecia
• Band test is done in SLE
• According to WHO, membranous glomerulonephritis seen in SLE, is Class V

These notes posted previously on Telegram channel by Venkat Raman

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